ReducING tardive dyskinesia (TD) with INGREZZA
Achieving Remission
No or minimal movements at 48 WEEKS in 59% of people*
Works Quickly
>5X TD Reduction at 2 WEEKS vs placebo†
Significant improvement‡
>10X TD Reduction at 6 WEEKS vs placebo§
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*In a post-clinical study evaluation of the KINECT 4 trial, 59% (61/103) of people who completed the trial taking INGREZZA (40 mg and 80 mg) achieved a score of 1 or less for each body part measured with AIMS at Week 48. The results are descriptive in nature.
†Reductions based on average change from baseline to Week 2 on an uncontrollable movement severity scale. Results for INGREZZA 80 mg —1.9 (n=77) vs placebo —0.3 (n=76) in a clinical study.
‡INGREZZA was studied in a 6-week clinical trial. A total of 234 people participated in the study. Results were based on 79 people taking the recommended dose of 80 mg.
§Reductions based on average change from baseline to Week 6 on an uncontrollable movement severity scale. Results for INGREZZA 80 mg —3.2 (n=70) vs placebo —0.1 (n=69) in a clinical study.
INGREZZA is proven to reduce TD, always one capsule, once daily, and #1 prescribed.
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A lot goes into being the #1 prescribed TD treatment:
- 27 clinical studies with over 1,470 people
- 7 years of real-world experience
- More than 1 million total prescriptions since 2017
- 3 simple and effective dosing options
- Starts at an effective dose
What makes INGREZZA different?
Unlike other TD medications, INGREZZA selectively and specifically targets a protein called VMAT2.‖ VMAT2 aids in the release of dopamine.
‖Based on laboratory tests. This does not imply a treatment advantage.
How INGREZZA works:
Some mental health medicines (antipsychotics) can cause abnormal dopamine signaling in the brain. This abnormal signaling can lead to uncontrollable body movements called tardive dyskinesia (TD).
Current research suggests that INGREZZA helps by correcting this abnormal dopamine signaling; however, how INGREZZA works to treat TD is not fully understood.
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Dopamine is a chemical in the brain that helps control movement.
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TD may be caused by too much dopamine signaling in the brain.
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INGREZZA selectively and specifically targets VMAT2,‖ a protein that aids in the release of dopamine…
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…which is believed to reduce this abnormal dopamine signaling.
‖Based on laboratory tests. This does not imply a treatment advantage.
With INGREZZA, you can keep takING most mental health medicines.
In a clinical study, psychiatric status remained stable overall in people taking INGREZZA for TD, including those who were also taking medicine for:
- Depression
- Bipolar disorder
- Schizophrenia/schizoaffective disorder
- Anxiety disorder
For questions about INGREZZA, call 1-84-INGREZZA (1-844-647-3992)
Did you know?
TD is unlikely to get better on its own. So, it’s important to take control and talk to your healthcare provider about treatment.
Common side effects of INGREZZA in people with tardive dyskinesia
The most common side effects of INGREZZA or INGREZZA SPRINKLE in people with tardive dyskinesia are sleepiness and tiredness.
What should I do if I experience side effects?
These are not all of the possible side effects of INGREZZA or INGREZZA SPRINKLE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.
Ready to take the next step?
Find a specialist.
INGREZZA is a treatment that’s
always one capsule, once daily,
and #1 prescribed.
See how INGREZZA helped make a difference in people’s lives.
Amy, real patient with TD
